Concomitant and Controllable Chiral/Racemic Polymorphs: From Achirality to Isotactic, Syndiotactic, and Heterotactic Chirality

摘要

Supramolecular chirality, which is ubiquitous in natural substances, has now become one of the central issues of chemistry in both the academic and industrial sectors. Spontaneous resolution, such that the enantiomers are segregated upon crystallization, stands out in the separation and control of chirality, and is widespread in the materials science of chiral crystalline solids, liquid crystals, and monolayers. Notably, the phenomenon of achiral components resolving to yield chiral crystals is relatively rare compared to the analogous process with chiral components or auxiliaries. Therefore, a series of scientific questions arise: are there enantiophobic and enantiophilic molecules? Or are packing forces responsible for conglomerate formation?