Organocatalytic Enantioselective Cascade Michael-Aldol Condensation Reactions: Efficient Assembly of Densely Functionalized Chiral Cyclopentenes

摘要

The development of asymmetric methods for the preparation of functionalized cyclopentenes has been of long-standing interest to organic chemists. As a result of their broad applications in organic synthesis they are widely distributed in a vast array of bioactive molecules. In the past, significant advances have been made in this area by using transition-metal-mediated [3+2] and [4+1] cycloaddition reactions. Furthermore, stereospecific ring opening of chiral cyclopro-panes, ring-closing metathesis of chiral dienes, and organ-ometallic-catalyzed Nazarov cyclizations have also been described.