Molecular Mechanisms in Skin Aging

摘要

The molecular events underlying skin aging have been carefully studied. Signaling pathways induced by UV light lead to sequential events culminating in an increase in collagen degradation and a decrease in collagen formation.This article reviews the mechanisms underlying these pathways and discusses how various therapeutic modalities intervene at specific sites in the pathways. As the population ages, there is great interest in addressing an aged appearance. Skin is the largest organ, and its appearance conveys one's health, lifestyle, and overall well-being. Aging skin is characterized by uneven pigmentation, laxity, and wrinkles