Eryptotic red blood cell adhesion to vascular endothelium:CXCL16/SR-PSOX, a pathological amplifier. Focus on 'Dynamic adhesion of eryptotic erythrocytes to endothelial cells via CXCL16/SR-PSOX'

摘要

the study by lang and colleagues (2), published in this issue, shows that red blood cells (RBCs), undergoing suicidal death or "eryptosis," attach to human umbilical vascular endothelial cells (HUVECs) under experimental flow conditions via their CXC ligand 16 (CXCL16)/SR-PSOX transmembrane ligands with the potential to greatly impact the microvascular circulation. CXCL16, a chemokine with a cysteine-X-cysteine motif, occurs either in soluble form or as a transmembrane receptor (16) that can be tyrosine phosphorylated and bind Src homol-ogy 2-containing proteins; it is synonymous with SR-PSOX, the scavenger receptor for phosphatidylserine (PS) and oxidized low-density lipoproteins (oxLDL) (19). Here, I review developments that underlie this discovery (2), emphasizing the complex cellular mechanisms of erythrocyte-augmented/induced vascular occlusion in conjunction with their suicidal death (eryptosis).