Sorting out noncanonical, paracrine functions of vitamin D. Focus on 'Vitamin D receptor activation and downregulation of renin-angiotensin system attenuate morphine-induced T cell apoptosis'

摘要

in a recent issue of AJP-Lung, Li et al. (22) report that the cystic fibrosis transmembrane conductance regulator (CFTR) is required for cAMP-stimulated liquid absorption in the alveolar epithelia. Using the cystic fibrosis (CF) pig model, they examined the ion and water transport properties of isolated type II alveolar epithelial cells (AEC). Although there have been studies on the role of CFTR in fluid transport in intact rabbit (29), rat (17, 35), mouse lung (9), and cultured human type II AEC (10), Li et al. (22) examined this process in the newly developed pig model for CF, which not only allows for a species comparison but also offers the exciting potential for following ion and fluid transport in an animal model for CF that appears to mimic many of the pathological features of lung disease found in CF patients (1, 27, 28, 30, 36); for an excellent review of the porcine lung as a model for CF see Ref. 32.