Uncovering the pathway of sepsis-induced renal tubular dysfunction. Focus on Basolateral LPS inhibits NHE3 and HCOFormula absorption through TLR4/MyD88-dependent ERK activation in medullary thick ascending limb'.

摘要

sepsis is the body's systemic response to severe infection, and it is associated with multiple organ dysfunction (e.g., neurological, pulmonary and renal). Indeed, severe sepsis affects millions of patients each year with a mortality rate'between 30% and 40% (2). During sepsis, arterial blood pressure drops significantly leading to sepsis-induced hypotension in septic shock. This drop in blood pressure is due to the activation of a complex hemodynamic response, which, in the kidney, leads to vaso-constriction and low renal blood flow followed by renal tissue hypoxia, ischemia, and rapid loss of kidney function (10).