Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48~/~Lepob/ob mice devoid of ApoE or Ldlr

摘要

in recent years, the metabolic syndrome has been increasingly recognized by clinicians as a major risk factor for cardiovascular disease and diabetes (28, 32, 36). Although the definition varies, it generally involves three of the following abnormal metabolic parameters (13, 41): central obesity (with excessive fat tissue in and around the abdomen), atherogenic dyslipide-mia [mainly high triglycerides and low high-density lipopro-tein (HDL)], insulin resistance or glucose intolerance, hyper-glycemia, and elevated blood pressure.