Three weeks of early-onset exercise prolongs obesity resistance in DIO rats after exercise cessation

摘要

Exercise has long been known to affect energy balance, and some humans who successfully maintain weight loss for several years self-report high levels of physical activity (8, 17,66, 73). In some instances, such self-reported exercise is associated with a normalization of resting energy expenditure in weight-reduced individuals (74). Because of the powerful forces opposing prolonged weight loss, it is likely that prevention of obesity, particularly in children would be a preferred means of stemming the obesity epidemic. While multiple studies have examined the effects of exercise on energy homeostasis in adult rodents (6, 37, 51), only a few have examined early-onset exercise in juvenile animals and explored the possibility that this might prevent the development of obesity (25, 32, 33, 52,64,76).