Analysis of L-NAME-dependent and -resistant responses to acetylcholine in the rat

摘要

acetylcholine activates vascular endothelial muscarinic receptors, leading to the formation of a factor or factors that relax the vascular smooth muscle (19, 20). Although evidence hi the literature indicates that the endothelial'-derived relaxing factor is nitric oxide (NO), in large arteries, the results of many studies indicate that more than one factor is involved in mediating cholinergic vasodilator responses (2, 4, 5, 7, 19, 20, 31, 41). Moreover, the factors and mechanisms that mediate endothelial-dependent vasodilation vary with species, vascular bed, and the vessel size studied (11, 19, 25, 26, 31, 32, 41).