The impact of aging on kidney repair

摘要

In addition to the inherent differences in susceptibility of the aged kidney to injury, the systemic impact of the aging process often results in exposure of patients to renal stressors such as nephrotoxic drugs, invasive interventions, and systemic diseases (18). Combined, these factors result in a higher incidence of AKI in the aging population. Since the population over the age of 65 yr will more than double globally by 2025 (102), we can expect an important rise in the number of elderly patients with AKI. The current means of treating AKI remain limited, and there are no specific strategies to adapt treatment options to the aging patient. A better understanding of how the old kidney differs in its susceptibility and response to injury is a necessary first step toward providing preventative strategies and therapeutic treatments that are tailored toward the elderly.