modeling of human disease in animals forms the basis of much of biomedical research. Animal models have been used to explore normal physiology, the pathophysiology of human disorders, and to test the safety and efficacy of new therapies in preclinical studies. In the field of lung research, much of our understanding of lung physiology under normal and pathological conditions derives from classic studies in dogs and sheep, including studies of normal pulmonary function by Julius Comroe (6), studies of the distribution of ventilation and perfusion by James West (25), studies of the pulmonary vasculature and alveolar surface tension by Solbert Permutt (10, 18), and studies of the mechanisms of formation of pulmonary edema by Norman Staub (23, 24) and the resolution of pulmonary edema by Michael Matthay (15).
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机译：动物中人类疾病的建模是许多生物医学研究的基础。动物模型已被用于探索正常的生理学，人类疾病的病理生理学，并在临床前研究中测试新疗法的安全性和有效性。在肺研究领域，我们对正常和病理条件下的肺生理的大部分了解来自对狗和羊的经典研究，包括朱利叶斯·康罗（Julius Comroe）对正常肺功能的研究（6），对通气和灌注分布的研究。 James West（25），Solbert Permutt（10，18）研究肺血管和肺泡表面张力，Norman Staub（23，24）研究肺水肿的形成机理，Michael研究肺水肿的缓解马特海（15）。
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