Regulation of cell proliferation by intermediate-conductance Ca~(2+)-activated potassium and volume-sensitive chloride channels in mouse mesenchymal stem cells

摘要

mesenchymal stem cells (MSCs) from bone marrow are plu-ripotent adult stem cells that can differentiate into a broad spectrum of cells, including osteoblasts, chondrocytes, adipo-cytes, neurons, skeletal muscle cells, and cardiomyocytes (25, 31) 43). Multidisciplinary researchers have paid great attention to MSCs, which have been considered as a source of cells for cell-based therapy in regenerative medicine, especially in re-Pair of damaged myocardium (24, 27).Clinical trials showed that implantation of human MSCs into mfarcted myocardium tissues improved cardiac function (39). Although the therapeutic effects are encouraging, potential Proarrhythmic effect of transplanted MSCs was observed in both in vitro and in vivo studies (5)