Evidence for chemicals sensitizing discharge from skeletal muscle afferents supporting cardiorespiratory reflexes during simulated exercise

摘要

the chemical metabolites in skeletal muscle that sensitize the activity of small-diameter afferents and support increases in cardiorespiratory function during exercise have been the subject of much investigation with a variety of methods. The chemicals that change within muscle with exercise have become better known, thanks to improved methods, but not all of these chemicals appear to contribute to these responses (9). One type of direct test is whether or not identified single unit afferent discharge is sensitized by these chemicals or diminished through use of appropriate antagonists in conditions simulating exercise. At least some of the adequacy of the evidence rests with strengths and potential weaknesses of how one models exercise while monitoring this activity. Furthermore, there are often additional implications once a substance is identified, in this case (6), through the contribution of cyclooxygenase products