Asymmetric synthesis of hexahydropyrrolo-isoquinolines by an organocatalytic three-component reaction

摘要

Merging three in one by a three-component organocatalytic asymmetric reaction of imines and α-bromoesters or ketones with α,β- unsaturated aldehydes provides optically active pyrrolo-isoquinolines-an important class of molecules in life science. The reaction proceeds with excellent enantioselectivity and a number of transformations of the products obtained demonstrated the potential of the new reaction.