Aryl phosphoramides: useful electrophiles for suzuki-miyaura coupling catalyzed by a NiCl_2/dppp system (dppp=1,3-bis(diphenylphosphino) propane)

摘要

Chemical Equation presantation Suzuki-Miyaura coupling: We disclose a new strategy for phenol activation in the first Suzuki-Miyaura coupling of phenol derivatives activated by forming aryl bis(2-oxo-3-oxazolidinyl)phosphines as a highly efficient and broadly applicable methodology for the diverse synthesis of biaryls and heterobiaryls (see scheme). The use of readily available, stable NiCl_2/dppp as the catalyst system also provides an important advance.