Primary compensatory adaptive reaction of Columba livia hepatocytes to hyperthermia: Changes in structure and metabolism

摘要

According to the hypothesis of "energy need" cytophysiological compensations of the rapid response to a single short-term rise in ambient temperature in birds of Columba livia species, occur in hepathocytes at the expense of metabolic depression, which is expressed as a decrease in the activity of the enzymes involved in the Krebs cycle and their cytoplasmic forms. The activity of G-6-PDH increases, thus demonstrating the adaptive metabolic plasticity of the antioxidant system. The flow of metabolites switches from aerobic to anaerobic route of glucose oxidation, the process of programmed cell death on the way of apoptosis is activated, the fraction of hepathocyte population at the G0 stage increases, while the fraction of hepathocytes at M stage of the cell cycle corresponds to this index in intact individuals.