The DNA methylome: a novel biomarker.

摘要

In this issue of Blood, Chambwe and colleagues demonstrate the presence of promoter methylation variability-in diffuse large B-cell lymphomas (DLBCLs).1 This methylation variability correlates with the expression of specific genes and is associated with distinct survival following standard therapy—a finding that has numerous implications for our understanding of the pathogenesis of these tumors.