Acute megakaryoblastic leukemia

摘要

A 46-year-old woman presented with diffuse bone pain. She had a history of acute myeloid leukemia with minimal differentiation (AML-MO) and normal karyotype diagnosed 15 months ago, achieved complete remission (CR) 1 month after beginning induction chemotherapy, and received 3 cycles of consolidation chemotherapy until 10 months before her current presentation. A complete blood count and peripheral smear at this time showed pancytopenia (hemoglobin 10.2 g/dL, white blood cells 3.8 X 109/L, platelets 67 X 109/L) and 37% blasts. The bone marrow was packed (95% cellularity) with immature myeloid cells that stained positively for CD13. CD33. CD41. CD61, and factor VIE and negatively for myeloperoxidase and CD3.