miR-155 is differentially expressed in Treg subsets, which may explain expression level differences of miR-155 in HIV-1 infected patients

摘要

We read with interest the article by Bignami et al that examined the miRNA profile of CD4~+ T lymphocytes from patients infected with HIV-1 (long-term non-progressors or treatment naive) versus subjects multiply exposed but uninfected (MEU). One of the main findings was the differential expression of only a single miRNA, miR-155, between LTNP and naive HTV-1 infected patients whereas there were many more differentially expressed miRNAs noted between HTV-1 infected patients and MEU. It was suggested that the up-regulation of miR-155 in naive HTV-1 infected patients may contribute to pathogenesis.