Successful treatment with infliximab despite positive tuberculosis ELISpot results in a patient with pityriasis rubra pilaris taking prophylactic isoniazid.

摘要

Pityriasis rubra pilaris (PRP) is an uncommon ery-thematosquamous skin disease of unknown aetiology, characterized by follicular hyperkeratotic papules and palmoplantar hyperkeratoses, sometimes leading to ery-throderma. Six subtypes of PRP have been described, and most cases occur spontaneously. A number of treatments, including systemic retinoids and steroids, methotrexate, fumaric acid, ciclosporin, phototherapy, vitamin D analogues, keratolytics and biologicals have been tried, with varying response rates. We report a patient treated successfully with infliximab.A 56-year-old white patient presented with lesions on his face and trunk. The patient's personal and family medical history were unremarkable. Systemic treatment with acitretin 40 mg daily for 6 months and topical therapy with corticosteroids, emollients and salicylic acid had not led to stable remission.