Comparison of efficacy and diffusion of three formulations of botulinum toxin type A in two patients with forehead hyperhidrosis

摘要

A number of studies have shown botulinum toxin type A (BoNTA) to be a very effective treatment for focal hyperhidrosis. However, the different formulations of BoNTA are not identical. They may differ in terms of both their electrophysiological and clinical behaviour, and results obtained with one formulation cannot therefore be extrapolated to another. As a result, different formulations may have different efficacy and tol-erability profiles. The literature contains few reports of direct comparisons of different formulations of BoNTA. Some studies have suggested that the diffusion of BoNTA2 (Dysport; Ipsen Ltd., Slough, UK) is greater than that of BoNTA 1 (BOTOX; Allergan, Inc., Irvine, CA, USA). In this study, we directly compared the efficacy and diffusion characteristics of three different formulations in two patients with forehead hyperhidrosis, including the new BoNTA3 (NABOTA, Daewoong, Co. Ltd., Seoul, Korea). We also investigated the diffusion area of the products to assess the area of effective action at the target site and to allow minimization of adverse effects.