Comparative Efficacy of Fixed Dose Combinations of Enalapril With Hydrochlorthiazide and Captopril With Hydrochlorthiazide in Patients With High Risk Hypertension.

摘要

Clinical effectiveness and tolerability of o.d. use of fixed dose combinations of enalapril (10 mg) with hydrochlorthiazide (25 mg) (Enap H) and captopril (50 mg) with hydrochlorthiazide (25 mg) (Capozide) were compared in a randomized study on 60 patients with I—II degree high and very high risk hypertension. Study duration was 6 months, number of patients in each of parallel groups — 30. Antihypertensive activity, ability to improve arterial elasticity and T/P parameter, cost/efficacy index of enalapril (10 mg) plus hydrochlorthiazide (25 mg) combination was found to be superior to those of captopril (50 mg) plus hydrochlorthiazide (25 mg) combination.