Prognostic significance of troponin T and MB creatine kinase elevations after percutaneous coronary interventions in patients with ischemic heart disease

摘要

AIM: To compare prognostic significance of troponin T (TnT) and MB creatine kinase (MB CK) elevations after percutaneous coronary interventions (PCI). MATERIAL AND METHODS: Patients with ischemic heart disease (n=122) were followed for 9+/-3 months after PCI. Coronary angiography was repeated in 79% of cases. Composite criterion of prognostic significance comprised coronary death or nonfatal myocardial infarction. RESULTS: Elevations of TnT , > or =0.03 ng/ml were noted in 55.5%, > or =0.1 ng/ml--in 21.9% of patients. Elevations of MB CK above upper limit of norm (ULN) were noted in 10.7% of patients. In 3 patients MB CK exceeded 3 ULN. Composite endpoint was registered in 53 patients (43.4%). There was no relation between any postprocedural elevation of MB CK and outcomes of follow-up. Levels of TnT between 0.03 and <0.1 hg/ml also were not related to prognosis. Post PCI TnT levels, > or =0.1 ng/ml were associated with significant worsening of prognosis during subsequent 6-12 months of follow-up.