The R implementation of the CRAN package PATHChange, a tool to study genetic pathway alterations in transcriptomic data

摘要

Tools that extract phenotype alterations from transcriptomic data are important to improve the interpretation of biological studies. PATHChange is a statistical CRAN package designed to work with data downloaded from the Gene Expression Omnibus database (GEO) to determine differential pathway expression in comparative studies including control samples. In this paper we present details of the structure, implementation and an example of use of the package. (C) 2016 Elsevier Ltd. All rights reserved.