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首页> 外文期刊>Comptes Rendus Chimie >Silica gel-supported tungstic acid (STA): A new, highly efficient and recyclable catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione carbonitriles and carboxylates under neat conditions
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Silica gel-supported tungstic acid (STA): A new, highly efficient and recyclable catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione carbonitriles and carboxylates under neat conditions

机译:硅胶负载的钨酸(STA):一种新型,高效且可回收的催化剂,可在纯净条件下合成1H-吡唑并[1,2-b]酞嗪-5,10-二酮腈和羧酸盐

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摘要

1H-Pyrazolo[1,2-6]phthalazine-5,10-dione carbonitriles and carboxylates possess a broad range of applications as active compounds in the pharmacological and biological fields. We developed an efficient and ecofriendly silica gel-supported tungstic acid (STA)-catalyzed one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione carbonitriles and carboxylates by a three-component reaction of an aldehyde, a malononitrile/ethyl cyanoacetate and a phthalhydrazide under solvent-free conditions. The major advantages of the present method are experimental simplicity, use of an inexpensive and ecofriendly reusable catalyst, good yields, and short reaction times. (C) 2014 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
机译:1H-吡唑并[1,2-6]酞嗪-5,10-二酮腈和羧酸盐在药理和生物学领域中作为活性化合物具有广泛的应用。我们开发了一种高效且环保的硅胶负载的钨酸(STA)催化的一锅式合成1H-吡唑并[1,2-b]邻苯二甲腈5,10-二酮腈和羧酸盐的三组分反应乙醛,丙二腈/氰基乙酸乙酯和邻苯二甲酰肼在无溶剂条件下使用。本方法的主要优点是实验简单,使用便宜且生态友好的可重复使用的催化剂,良好的收率和较短的反应时间。 (C)2014年科学研究院。由Elsevier Masson SAS发布。版权所有。

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