Degradation of Polyaminophosphazenes: Effects of Hydrolytic Environment and Polymer Processing

摘要

Polyphosphazenes with amino acid ester side groups show potential as hydrolytically degradable materials for biomedical applications.This study focuses on practical aspects of their use as biodegradable materials,such as effects of the hydrolytic environment and sample processing.Poly[di(ethyl glycinato)phosphazene],PEGP,and poly[di(ethyl alaninato)phosphazene],PEAP,were prepared by macromolecular substitution reaction,ensuring the absence of the residual chlorine atoms to avoid their influence on the hydrolysis.The kinetics of polymer degradation was studied by simultaneously measuring polymer mass loss,molecular weight decrease,and the release of phosphates and ammonia.The effect of pH,buffer composition,temperature,casting solvents,and film thickness were investigated.