Synthesis of a chitosan-dendrimer hybrid and its biodegradation

摘要

Chitosan-dendrimer hybrids having various functional groups such as carboxyl,ester,and poly(ethylene glycol) groups were prepared successfully using dendrimer acetal by reductive N-alkylation.The synthetic procedure could be accomplished by one-step reactionwithout organic solvent.The degree of substitution of dendrimer was 0.13-0.18 evaluated by ~1H NMR.A perfectly or partially water-soluble chitosan-dendrimer hybrid could be obtained.By standard activated sludge,good biodegradation was observed in these hybrids.