Systemic sclerosis (SSc) presents a great deal of variability in the extent and severity of skin and internal organ involvement The diagnostic and prognostic significance of autoantibodies in SSc is undisputed and the patient's au-toantibody profile represents a fundamental tool for clinicians. Scleroderma is a rare condition in children. Unlike adults, localized scleroderma is more frequent than the systemic sclerosis, nevertheless it represents a disabling condition. In both conditions, no validated outcome measures and proven effective treatment is available to date.. Raynaud's phenomenon (RP) is one the most common and significant clinical symptoms of SSc and therefore in patients with RP a capillaroscopic analysis should be carried out as soon as possible. The actual and select advantage of the early nailfold videocapil-laroscopic (NVC) analysis is to distinguish between the primary RP and the secondary RP and to allow the early detection of SSc.
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