In the 1920s, Otto Warburg and his group at the Kaiser Wilhelm Institute noted the importance of glycolysis to proliferating normal and malignant tissue, formulating the 'no growth without glycolysis' dictum.1-2 Consistent with Warburg^s observations, Agathocleous etal? have recently shown that the embryonic frog (Xenopus laevis) retina tends to divert energy metabolism away from oxi-dative phosphorylation and produce adenosine triphos-phate via the conversion of pyruvate to lactate, despite the presence of oxygen, a phenomenon known as aerobic glycolysis or the Warburg effect.
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机译：在1920年代，奥托·沃伯格（Otto Warburg）和他在凯撒威廉研究所（Kaiser Wilhelm Institute）的研究小组注意到糖酵解对于增生正常和恶性组织的重要性，并提出了“不进行糖酵解就不会生长”的法则。1-2与沃伯格的观察一致，无藻等？最近的研究表明，尽管存在氧气，但即使存在氧气，胚胎青蛙（Xenopus laevis）的视网膜也倾向于将能量代谢从氧化型磷酸化转移出去，并通过丙酮酸转化为乳酸生成三磷酸腺苷。这种现象被称为有氧糖酵解或沃堡效应。
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