Perfluoroalkylation of 6-Iodopurines by Trimethyl(Perfluoroalkyl)Silanes. Synthesis of 6-(Perfluoroalkyl)Purine Bases, Nucleosides and Acyclic Nucleotide Analogues

摘要

A CuI/KF mediated perfluoroalkylation reaction of various 9-substituted 6-iodopurines 1 with trimethyl(trifluoromethyl)silane or heptafluoropropyl(trimethyl)silane was used for the synthesis of the corresponding 6-(trifluoromethyl)- and 6-(heptafluoropropyl)purine derivatives (purine bases, nucleosides and acyclic nucleotide analogues) in moderate to good yields.