Changes in SOD-1 gene expression in the tissues of germ-free hSOD-1 transgenic mice

摘要

Recent research on reactive oxygen species (ROS) has been remarkable, and gene expression and signaling mechanism associated with ROS generation or elimination have been demonstrated at a genetic level. In addition, recent studies have suggested thatROS functions as a secondary messenger in a variety of physiological processes. Among ROS, superoxide (O_2~-), which is a free radical, is generated in phagocytes and plays an important role in the phagocytosis of foreign bodies. However, increased O_2~- production leads to tissue damage. Superoxide dismutase (SOD), which plays an anti-oxidant role, catalyzes the breakdown of O_2~- into hydrogen peroxide and water and is therefore a central regulator of ROS levels.