Prognostic Impact of Tumoral and/or Peri-Tumoral Stromal SPARC Expressions After Surgery in Patients With Biliary Tract Cancer

摘要

Background and ObjectiveSPARC (secreted protein acidic and rich in cysteine) is a matricellular glycoprotein that modulates interactions between tumoral cells and the peri-tumoralstroma. SPARC induces proliferation and invasion in vitro, and is a poor prognostic factor in several gastrointestinal cancers. Herein, we evaluated the prognostic value of tumoral and stromal SPARC expression in patients with biliary tract cancer (BTC) after surgery.