Syntheses, structural characterizations and properties of 12-MC-4 organotin(IV) metallacrowns: [12-MC_(RSn(IV)N(shi))-4] and [12-MC _(RSn(IV)N(Clshi))-4] (R = Et, Bu, Ph; H_3shi = salicylhydroxamic acid; H_3Clshi = 5-chlorosalicylhydroxamic acid)

摘要

Five 12-MC-4 organotin(IV) metallacrowns(MCs) with the types of [12-MC _(RSn(IV)N(shi))-4] (R = Et (1), Bu (2), Ph (3); H_3Shi = salicylhydroxamic acid) and [12-MC_(RSn(IV)N(Clshi))-4] (R = Et (4), Bu (5), H_3Clshi = 5-chlorosalicylhydroxamic acid) have been synthesized and characterized by elemental analyses, IR and TGA. X-ray single-crystal diffraction analyses were also carried out and showed that all complexes 1-5 contain a neutral 12-membered metallacrown ring which is formed by the succession of four repeating units of -[Sn-N-O]-, indicating the substituents on the tin(IV) atom are uninfluential in coordination of organotin(IV) centers with hydroxamic acid. Fluorescence properties of complexes 1-5 have been investigated, where complex 3 displays strong fluorescence emissions in the blue region. In addition, antitumor activities of complexes 4 and 5 have also been tested, and both the complexes exhibit weak activity towards human hepatocellular carcinoma cell line (Bel-7402) and Hela cell line. Five 12-MC-4 organotin(IV) metallacrowns(MCs) with the types of [12-MC _(RSn(IV)N(shi))-4] (R = Et (1), Bu (2), Ph (3); H_3shi = salicylhydroxamic acid) and [12-MC_(RSn(IV)N(Clshi))-4] (R = Et (4), Bu (5), H_3Clshi = 5-chlorosalicylhydroxamic acid) have been synthesized and characterized by elemental analyses, IR, TGA and X-ray single-crystal diffraction analyses, which showed that the substituents on the tin(IV) atom are uninfluential in coordination of organotin(IV) with hydroxamic acid. Fluorescence properties of complexes 1-5 have been investigated, where complex 3 displays strong fluorescence emissions in the blue region, antitumor activities of complexes 4 and 5 have also been tested, both the complexes exhibit weak activity towards human hepatocellular carcinoma cell line (Bel-7402) and Hela cell line.