Metal complexes-catalyzed hydrolysis and alcoholysis of organic substrates and their application to kinetic resolution

摘要

Metal complexes-catalyzed hydrolysis and alcoholysis of organic substrates such as alkenyl esters, alkenyl ethers, and azlactones (oxazol-5(4H)-ones) are described. These reactions were applied for kinetic resolution of chiral compounds and high selectivities were achieved with vinyl ethers of 2-substituted cyclohexanols, 1,1'-bi-2-naphthols, 1,1'-bi-2-phenols, and 4,4-disubstituted aziactones. Oxidative carbon-carbon bond cleavage reactions, which were found in the course of the study of asymmetric hydrolysis were also described. (c) 2006 Elsevier B.V. All rights reserved.