To validate micro-lightguide spectrophotometry (O2C) in patients with lower limb ischemia and to compare results with those obtained from toe blood pressure. We prospectively examined 59 patients, 24 of whom complained of claudication, 31 had critical ischemia, and four were asymptomatic. Diabetes was present in 19 (32%) patients. Saturation (SO 2) and flow measured with O2C were determined with the limb in the horizontal position followed by a 55-cm elevation. Toe pressures were determined in the horizontal position only. In addition, 13 patients were examined before and, on average, 3 days after revascularization. Median SO 2 was 62% (25%-75% percentile: 37%-75%) with the limb in the horizontal position and 16% (3%-41%) with the limb elevated. Comparing the individual toe pressures with SO 2 values measured in the horizontal position and elevated position revealed a significant correlation (r s = 0.40; P .01 and r s = 0.56; P .01, respectively). A low SO 2 (ie, 40% in the horizontal position and 20% in the elevated position) was highly predictive of a toe pressure of 40 mm Hg or less. In the horizontal position, the positive predictive value was 100%, whereas the negative predictive value was 47%. The similar figures in the elevated position were a positive predictive value of 97% and a negative predictive value of 68%. Postoperatively, SO 2 increased significantly from 27% (P25%-75%: 11%-75%) to 79% (68%-87%) in the horizontal position (P = .008) and from 14% (P25%-75%: 2%-39%) to 55% (30%-73%) in the elevated position (P = .011), respectively. Looking at the individual 13 cases in which revascularization was performed, three patients had a partial reconstruction (ie, superficial femoral artery occlusion distal to a central reconstruction or reconstruction to a popliteal blind segment). These patients had significantly lower postoperative SO 2 as well as toe pressure compared with the 10 patients with unobstructed flow to the foot. O2C was easy to use, fast, and painless. The most useful finding was the high predictive value of a low saturation and the rise in O2C values after successful revascularization.
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机译：为了验证下肢缺血患者的微光导分光光度法（O2C），并将结果与从脚趾血压获得的结果进行比较。我们前瞻性地检查了59例患者，其中24例抱怨complain行，31例有严重缺血，4例无症状。 19名（32％）患者患有糖尿病。肢体处于水平位置，然后抬高55厘米，确定饱和度（SO 2）和O2C测得的流量。脚趾压力仅在水平位置确定。另外，在血运重建之前和平均之后3天检查了13例患者。肢体处于水平位置时，SO 2的中位数为62％（25％-75％百分数：37％-75％），肢体升高时中位SO 2为16％（3％-41％）。将各个脚趾压力与在水平位置和升高位置测得的SO 2值进行比较，发现存在显着相关性（r s = 0.40; P <.01和r s = 0.56; P <.01）。 SO 2低（即，水平位置<40％且升高位置<20％）可高度预测趾压为40 mm Hg或更小。在水平位置，阳性预测值为100％，而阴性预测值为47％。升高位置的相似数字为阳性预测值97％和阴性预测值68％。术后，SO 2在水平位置（P = .008）从27％（P25％-75％：11％-75％）显着增加到79％（68％-87％），从14％（P25％- 75％：2％-39％）到55％（30％-73％）的位置（P = .011）。在对进行血运重建的13例患者中，有3例患者进行了部分重建（即中央重建远端的股浅动脉阻塞或pop门盲段重建）。与10例足部通畅患者相比，这些患者的术后SO 2和脚趾压力明显更低。 O2C易于使用，快速且无痛。最有用的发现是血运重建成功后低饱和度的高预测值和O2C值升高。
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