Akt and mitogen-activated protein kinase enhance C-type lectin-like receptor2-mediated platelet activation by inhibition of glycogen synthase kinase 3 alpha/beta

摘要

BackgroundThe C-type lectin-like receptor2 (CLEC-2) and the collagen receptor glycoprotein (GP)VI activate platelets through Src and Syk tyrosine kinases, and phospholipaseC2. The initial events in the two signaling cascades, however, are distinct, and there are quantitative differences in the roles of proteins downstream of Syk activation. The activation of Akt and mitogen-activated protein kinases (MAPKs) has been shown to enhance platelet activation by GPVI, but their role in CLEC-2 signaling is not known.