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首页> 外文期刊>Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology >Gait disturbances in Parkinson disease. Did freezing of gait exist before levodopa? Historical review.
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Gait disturbances in Parkinson disease. Did freezing of gait exist before levodopa? Historical review.

机译:帕金森病的步态障碍。左旋多巴之前是否存在步态冻结?历史回顾。

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摘要

Gait disturbances occur frequently in advanced Parkinson's disease (PD) including slow gait, postural changes, festination and freezing of gait. We have reviewed descriptions of gait abnormalities in PD from classic predopa-literature and compared them with those found in contemporary references. Several components of gait disturbances associated with shaking palsy were very well known in classic literature. James Parkinson, Charcot, Gowers and Wilson described slowness of gait, postural changes, loss of postural reflexes and festination; according to James Parkinson, festination was a pathognomonic element in shaking palsy. In contrast, freezing of gait was rarely mentioned in historic literature save for anecdotal reports (Buzzard 1888). Freezing of gait was fully noticed after the chronic use of levodopa (Barbeau and Ambani). In this historical review, we analyze the concept, identification and evolution of gait disturbances in PD through the time.
机译:在晚期帕金森氏病(PD)中,步态障碍经常发生,包括缓慢的步态,姿势变化,预想和步态冻结。我们回顾了经典多多巴前期文献对PD步态异常的描述,并将其与当代文献中的相比较。在经典文献中,与麻痹相关的步态障碍的几个组成部分是众所周知的。詹姆士·帕金森(James Parkinson),夏洛特(Charcot),高尔斯(Gowers)和威尔逊(Wilson)描述了步态缓慢,姿势改变,姿势反射丧失和节制。根据詹姆士·帕金森(James Parkinson)的说法,喜怒无常是震动麻痹的一种致病因素。相反,除了传闻(Buzzard 1888),在历史文献中很少提到步态冻结。长期使用左旋多巴(Barbeau和Ambani)后,步态完全冻结。在此历史回顾中,我们分析了PD步态障碍的概念,识别和演变。

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