From quality of publication to quality of care: translating trials to practice.

摘要

Results from randomized controlled trials (RCTs) can have an immediate impact on patient care. Accurate and complete reporting is essential to determine whether trial design, conduct, and analyses are scientifically creditable. Consolidated Standards of Reporting Trials (CONSORT) require explicit reporting of specific components of trial methodology necessaiy to allow readers to accurately assess trial validity (1-3). Trial information should also be informative, allowing readers to determine whether the results are able to be generalized to non-trial patients and whether the risk to benefit ratio of the intervention is medically acceptable. Although adherence to CONSORT guidelines allows reviewers, journal editors, and readers to judge the quality of trial methodology and validity of results, these guidelines do not necessarily ensure the reporting of sufficient information for quality application of treatment within the broad clinical community following trial publication.