Synthesis of a clathrate host for formamides, N-[2-(3,5-dinitrobenzoylamino)-6-methylphenyl]phthalimide, and analysis of the interactions in the host-guest complex

摘要

A clathrate host, N-[2-(3,5-dinitrobenzoylamino)-6-methylphenyl]phthalimide 1 is designed to achieve inclusion of N-substituted formamides. N,N-Dialkylformamides HCONR2 of various sizes 2a-e [2a: R = Me; 2b: R = Et; 2c: R = Pr-i; 2d: R-2 = -(CH2)(5)-, 2e: R-2 = -(CH2)(2)O(CH2)(2)-] and dimethyl sulfoxide have been included as the guests in a clathrate host 1, in the ratio 1 :1 in each case. The interaction between the host and guest has been investigated by X-ray analysis of complex 1 2e (1 : 1). The phthalimide plane and the N-phenyl group are orthogonal, which makes a suitable space for recognition of the formamides. [References: 18]