Efficacy of adenosylcobalamin in relieving xerotic pruritus symptoms of atopic dermatitis

摘要

Multiple treatment modalities have been used in the treatment of atopic dermatitis (AD), although long-term use of cortico-steroid has been associated with various adverse effects. Accordingly, a significant research effort now exists to identify steroid-sparing alternative therapeutic modalities, with topical vitamin B12 (adenosylcobalamin) potentially representing one specific agent. Emerging data indicate that cobalamin may prevent AD flares by reducing the production of nitric oxide (NO) and proinflammatory cytokines.To assess the efficacy of topical adenosylcobalamin in AD patients, we recruited the children between 2 and 12 years old diagnosed with AD. During 8-week treatment period, each patient was instructed to apply a vitamin B12-containing gel to all AD-affected area twice daily. The adenosylcobalamin gel was manufactured by HanAll BioPharma (Seoul, Korea). Specifically, the gel contains 0.07% of adenosylcobalamin by weight concentration in a moisturizer base.