ANTISCHISTOSOMAL EFFECTS OF PRAZIQUANTEL, ITS ALKALINE HYDROLYSIS AND SUN DECOMPOSED PRODUCTS ON EXPERIMENTALLY S. MANSONI INFECTED ALBINO MICE. (A) EFFICACY ASSESSMENT BASED ON CLINICOPATHOLOGICAL FINDINGS

摘要

The antischistosomal activity of piaziquantel (PZQ), its alkaline hydrolysis product (HP) and its sun-decomposed (SD) products was investigated in S. mansoni experimentally infected mice. The eval-uation was made depending on the degree of clinico-pat hological changes. The results obtained revealed that, PZQ, HP and the SD have induced partial suppression of worm fecundity as judged by the significant reduction in eggs per gram of faeces in comparison with the infected untreated control. The effect o n tissue egg deposi-tion in the treated groups was comparable to the infection of untrea ted control Worm recovery showed large reduction in the number of worms for SD (47..6%) and HP (28.6%) compared to PZQ (16.6%) treated groups. So, the former two com pounds have the superior antischistosomal activities. Glutamate pyruvate transom-inase (GPT) and glutamate oxaloacetate transaminase (GOT) concentrations were measured. The GOT values for all treated groups were significantly higher than those for the he althy control group (p=0.01). The SD group enzyme concentration was even higher than the infected untreated control. The GPT values of all groups were greater than the uninfected control and the difference was significant for the infected untreated, PZQ and the SD treated groups (p=0.05).