首页> 外文期刊>Journal of the Chemical Society of Pakistan >Launeugenol, a New Eugenol Derived Dimer from Launaea intybacea
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Launeugenol, a New Eugenol Derived Dimer from Launaea intybacea

机译:月桂香酚,一种新的丁香酚丁香油衍生的丁香酚二聚体

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摘要

A eugenol derived dimer (1) has been isolated from the methanolic extract of the whole plant of Launaea intybacea along with the three known compounds. The structures of all the isolates (1-4) were established using ID (~1H, ~(13)C) and 2D NMR (HMQC, HMBC, COSY) spectroscopy, mass spectrometry and comparison with the reported data in the literature. Compound 1 was tested for its DPPH radical scavenging and enzyme inhibitory activities against enzyme acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and lipoxygenase (LOX) and found to be moderately active against enzyme lipoxygenase with IC_(50) value of 56.3 μM.
机译:从丁香劳氏整株植物的甲醇提取物中分离出一种丁香酚衍生的二聚体(1)以及三种已知化合物。使用1D(〜1H,〜(13)C)和2D NMR(HMQC,HMBC,COSY)光谱学,质谱法和与文献中报道的数据进行比较,确定了所有分离株(1-4)的结构。测试了化合物1的DPPH自由基清除能力以及对乙酰胆碱酯酶(AChE),丁酰胆碱酯酶(BChE)和脂氧合酶(LOX)的酶抑制活性,发现其对脂氧合酶具有中等活性,IC_(50)值为56.3μM。

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