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摘要

A 3-year-old 37-kg (81.4-lb) castrated male Giant Schnauzer was evaluated for lymphadenopathy, weight loss, and lethargy. All identifiable external and internal lymph nodes were large, and cytologic examination of a prescapular lymph node aspirate revealed branching hyphae most consistent with aspergillosis. The dog was treated with liposome-encapsulated amphotericin B (100 mg, IV, 3 treatments each week, for a total dose of 1,000 mg). Despite histologic identification of mycosis, results of fungal cultures were negative, preventing differentiation of Aspergillus spp infection from infection with Zygomycetes or Paecilomyces spp. The dog was hospitalized during treatment and received fluids IV intermittently. Toward the end of the antifungal treatment, the dog became intermittently febrile. One inguinal lymph node further enlarged and eventually ruptured externally. Treatment with amoxicillin-clavulanic acid (20 mg/kg [9.1 mg/lb], PO) was initiated. Several days after completion of the anti-fungal treatment, the dog had acute signs of depression and a rectal temperature of 41.7°C (107°F). Results of CBC and serum biochemical analyses suggested sepsis, and the dog had signs of pain during palpation of the abdomen. Radiographs of the abdomen were obtained (Figure 1).