Is ventricular arrhythmia a possible mediator of the association between aortic stenosis-related midwall fibrosis and mortality?

摘要

In 1954, Mitchell et al. (1) reported on 40 years of experience with clinical features of 533 cases of aortic stenosis managed at the Peter Bent Brigham Hospital of Boston, Massachusetts. This patient series spanned the development of mercurial diuretics, surgical cure for aortic stenosis, and penicillin, advances that have transformed the epidemiology and prognosis of aortic stenosis. Several remarkable observations of this study remain central to the findings reported in this issue of the Journal. Mitchell et al. (1) noted significantly shorter expected survival after the onset of symptoms.