Renal denervation and left ventricular mass regression: A benefit beyond blood pressure reduction?

摘要

Population studies indicate a continuous association between an increase in attributable risk for cardiovascular disease with increasing blood pressure (BP) and age (1). Resistant hypertension, by definition, is the inability to reduce BP to levels < 140/90 mm Hg, despite adequate combinations of maximally tolerated doses of antihyper-tensive medications and lifestyle modifications (2). The longer history of higher sustained pressures, relative to those without resistant hypertension, increases the likelihood of end-organ injury such as left ventricular (LV) hypertrophy, subsequent heart failure, and progression of kidney disease.