Characterization of the adaptation module of the signaling network in bacterial chemotaxis by measurement of step responses

摘要

The bacterial chemotaxis network features robust adaptation implemented by negative integral feedback. Here, we show that the adaptation module can be characterized by measurement of the response to simple step-addition and removal of a chemoattractant. The method does not rely on a particular form of the receptor module, and thus can be used to characterize other integral feedback networks.