Adults with LCH--orphans with an orphan disease.

摘要

This conference was held at the Royal College of Physicians on 10-11 November 2005 and was organised in association with the Royal College of Paediatrics and Child Health and supported by the Leukaemia Research Fund. In the 1950s, Dr Sidney Farber (a clinician) and Dr Louis Lichtenstein (a pathologist) were the first to appreciate that three clinical entities - eosinophilic granuloma, Hand-Schuller-Christian disease and Letterer-Siwe disease - were variants of a single pathological process. Lichtenstein noted close histological similarity between them and coined the all-embracing term 'Histiocytosis X'. The term Xangerhans cell histiocytosis' (LCH) was adopted by the Histiocyte Society in 1989, after it had been shown that Langerhans-like cells are essential to confirm the diagnosis.