A one-step fully automated radio-synthesis of a dopamine transporter PET imaging agent 18F-FECNT and its in vivo evaluations

摘要

2β-Carbomethoxy-3β-(4-chlorophenyl)-8-(2-[~(18)F] fluoroethyl)nortropane ([~(18)F]-FECNT) is a potential dopamine transporter PET imaging agent. However, its current radio-synthesis is tedious and time consuming. In this article, we reported a fully automatic method for the synthesis of [~(18)F] FECNT through only one step, using a TRACERlab FX_N module, with decay corrected radiochemical yield of 25 ± 5 % (n = 5). The total synthesis time was 50-55 min. The synthesized [~(18)F]FECNT was evaluated in vivo in Parkinson's disease model rats.