Importance of DMSA stability, its consequence for Sn(DMSA)_2 complex formation and relevance to ~(99m)Tc-DMSA radipharmacs preparation

摘要

The dimercaptosuccinic acid (DMSA) stability at pH = 3.8, 7.1, 8.8 and the interaction with SnCl_2?2H_2O were investigated. The degradation of DMSA is the most significant at alkali pH. There where observed oxidized and dimerized forms of DMSA and fumaric acid presence. Progress of instability is less substantial and slower under neutral reaction conditions. At acidic pH the concentration of soluble DMSA decreases with the time. The ligand forms with SnCl_2 complex under alkali pH = 8.8 and its chemical formula was determined as Sn(DMSA)_2.