Synthesis and biological evaluation of fatty acids containing Tc-99m-oxo and Tc-99m-nitrido for myocardial metabolism imaging

摘要

In this study, four Tc-99m-labeled fatty acid analogues including [(TcO)-Tc-99m](3+) and [Tc-99m N](2+) cores were successfully synthesized and fully characterized. The radiochemical purity of those compounds was over 90 % and they were stable when incubated in a rat serum for 3 h at 37 degrees C. The biodistribution studies in mice demonstrated that compounds labeled with [(TcO)-Tc-99m](3+) exhibited good uptakes (6.11 % ID/g of [(TcO)-Tc-99m]-MAMA-DTA and 3.89 % ID/g of [(TcO)-Tc-99m]-MAMA-UTA at 1 min postinjection) and the maximum heart to blood ratio was 5.91 at 30 min postinjection of [(TcO)-Tc-99m]-MAMA-DTA. While the others labeled with [Tc-99m N](2+) showed lower uptakes and faster washout from the myocardium.